A NOVEL ANTAGONIST OF THE IMMUNE CHECKPOINT PROTEIN ADENOSINE A2A RECEPTOR RESTORES TUMOR-INFILTRATING LYMPHOCYTE ACTIVITY IN THE CONTEXT OF THE TUMOR MICROENVIRONMENT

BACKGROUND: Therapeutic strategies targeting immune checkpoint proteins have led to significant responses in patients with various tumor types.The success of these studies has led to the development of various antibodies/inhibitors for the different Cast Iron Cookware checkpoint proteins involved in immune evasion of the tumor.Adenosine present in

Objective: Rose oil is obtained from the petals of difference Rosa species especially Rosa centifolia L.and Rosa damascena Mill.Various pharmacological properties have been attributed to rose oil.The aim of the present study was to review the rose oil therapeutic effects which had been clinically evaluated in trial studies.Materials and Methods: Go

In this study, conceptual design for primary heat exchanger of the Molten Salt Fast Reactor is made.The design was carried out to remove Volumising Foam the produced heat from the reactor developed under the SAMOFAR project.Nominal power of the reactor is 3 GWth and it has 16 heat exchangers.There are several requirements related to the heat exchan

This paper aims at dissecting the criminal provisions on criminal enforcement of fines in current Romanian criminal law with the goal of highlighting the new penal policy stated in the larger field of criminal penalties.In the new Criminal Code the fine penalty experience a new regulation, SNACKS but also a wider scope compared to the Criminal Code

Abstract RSL1D1 (ribosomal L1 domain containing 1), a member of the universal ribosomal protein uL1 family, was suggested to be a new candidate target Tanks/Jerseys for colorectal cancer (CRC).However, the role of RSL1D1 in cancer, including CRC, remains largely elusive.Here, we demonstrated that RSL1D1 expression was significantly elevated in tumo